منابع مشابه
[Caloric restriction and anti-aging].
エレガンス線虫の寿命は約 3 週間で寿命の遺伝学的解 析に適している.研究室で実験に使っている野生型線虫 (N2)は,20°C で飼育すると,最大寿命が 21 日前後な ので,10 日目には中年特有の表現系を示すことが知ら れている.実際,顕微鏡で観察すると,10 日目には消 化管の周りの脂肪組織が急に黒ずんで目立つようにな る.この症状は脂肪細胞にトリグリセライドの蓄積が増 加するためで,ヒトにおける中年太りの内臓脂肪の蓄積 によく似た症状である. 代表的な長寿線虫,daf-2 変異体は最も遺伝解析が進 んでいる変異体である.daf-2 線虫は耐性幼虫(dauer) になりやすいことから daf(dauer formation,耐性幼虫 化)シリーズの名前が付いている.しかし,運動やリズ ムは正常で,一定温度(高温)で飼育する限り,耐性幼 虫化せずに,寿命は 1.5 倍~2 倍に延...
متن کاملSeminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging.
From the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Box 165, Rockefeller University, 1230 York Ave., New York, NY 10021, where reprint requests should be addressed to Dr. McEwen. ©1998, Massachusetts Medical Society. VER 60 years ago, Selye 1 recognized the paradox that the physiologic systems activated by stress can not only protect and restore but also damage the bod...
متن کاملEffect of fenfluramine on caloric intake and macronutrient selection in Lou/c rats during aging.
Previous studies have shown a shift of preferences from carbohydrate to fat and a decrease in protein intake in self-selected Lou/c rats with advancing age. This study investigated a potential neurochemical mechanism underlying age-related modifications by evaluating the effects of fenfluramine (dl-F), a drug that enhances 5-HT release and blocks its re-uptake by presynaptic terminals, on macro...
متن کاملMitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys
BACKGROUND A high-calorie (HC) diet induces renal injury and promotes aging, and calorie restriction (CR) may ameliorate these responses. However, the effects of long-term HC and CR on renal damage and aging have been not fully determined. Autophagy plays a crucial role in removing protein aggregates and damaged organelles to maintain intracellular homeostasis and function. The role of autophag...
متن کاملEffects of Obesity and Caloric Intake
A B S T R A C r The effects of obesity and caloric intake on biliary lipid metabolism were investigated in a series of related studies. The degree of saturation of gallbladder bile with cholesterol was found to be significantly higher in a group of 23 obese healthy subjects than in a group of 23 nonobese controls matched for age, sex, and race. Bile was also significantly more saturated in 11 o...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 1997
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejm199710023371407